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KMID : 1138520120150020007
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Journal of Pharmacopuncture
2012 Volume.15 No. 2 p.7 ~ p.10
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Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice
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Kim Han-Na
Kim Mi-Young
Choi Chan-Hun
Kim Byung-Joo
Kim Kyung-Yoon
Kim Gye-Yeop
Jeong Hyun-Woo
Kim Hyung-Woo
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Abstract
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Objective:The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis.
Methods:In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model.
Results:Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo.
Conclusion:These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.
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KEYWORD
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Lithospermi Radix, dinitrofluorobenzene, contact dermatitis, anti-allergic
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